Futures ease on rate-cut jitters ahead of inflation data, Fed meet
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Eli Lilly up as Alzheimer's drug gets US FDA panel backing
Crypto stocks fall as bitcoin hits one-week low
GM approves $6 billion share buyback plan
Futures lower: Dow 0.31%, S&P 0.22%, Nasdaq 0.23%
Updated at 8:16 a.m. ET/1216 GMT
By Lisa Pauline Mattackal and Johann M Cherian
June 11 (Reuters) - Wall Street was set to open loweron Tuesday, with futures tracking all three major indexes in the redas investors were cautious ahead ofcrucial inflation data and a policy announcement from the Federal Reserve expected this week.
The S&P 500 .SPX and the Nasdaq .IXIC posted record closing highs on Monday in a choppy session, boosted by shares of Nvidia NVDA.O after its 10-for-one stock split.
Markets are readying for Wednesday's release of the Consumer Price Index report for May andthe conclusion of the Fed's two-day policy meeting.
"There's an abnormal amount of anxiety around these numbers and around the Fed meeting, particularly after the jobs report on Friday," said Thomas Hayes, chairman at Great Hill Capital LLC.
The central bank is not expected to change rates but will release its updated economic projections and "dot plot", which shows where policymakers expect interest rates to stand over the next few years and longer term.
The CPI numbers and the Fed's projections will be closely scrutinized as recent reports have given conflicting signals on theeconomy's underlying health.
"If they (Fed policymakers) take down growth a bit, then they will have cover to keep two dots on the dot plot, which would be very bullish for markets. So this trepidation you're seeing is a fear of what if that doesn't happen," Hayes said.
Markets are pricing in a nearly 53% chance of theFed's first rate cut happening inSeptember, according to the CME's FedWatch tool. Rate futures also imply just one cut this year, compared to two before Friday's bumperNonfarm Payrolls data. FEDWATCH
Meanwhile, Nvidia ticked0.3% lower inpremarket trading, while shares of Apple AAPL.O lost 0.2% after investors were unimpressedby the long-awaited AI strategy presented at its developer conference on Monday.
Other rate-sensitive megacap stocks slipped, with Microsoft MSFT.O, Meta Platforms META.O and Amazon.com AMZN.O falling between 0.2% and 0.3%.
On the day, a National Federation of Independent Business survey showed small-business confidence and hiring plans increased to their highest levels of the year in May, but the upcoming U.S. presidential election drove the Uncertainty Index to a nearly four-year high.
At 8:16 a.m. ET, Dow e-minis 1YMcv1 were down 121 points, or 0.31% , S&P 500 e-minis EScv1 were down 12 points, or 0.22% , and Nasdaq 100 e-minis NQcv1 were down 44 points, or 0.23% .
Shares of prison operator CoreCivic CXW.N and Target Hospitality TH.O slumped 34.3% and 18.2%, respectively, after the U.S. Immigration and Customs Enforcement said it would close a Texas detention center.
Cryptocurrency-linked stocks slipped as bitcoin BTC= slid 3.7%, withbitcoin miners Riot Platforms RIOT.O and Marathon Digital MARA.O and crypto exchange Coinbase COIN.O falling between 2.5% and 3.5%.
General Motors GM.N gained 1.3 % after the automaker announced a $6 billion share buyback plan.
Eli Lilly's LLY.N shares rose2.1% after its Alzheimer's drug donanemab received unanimous backing from a U.S.FDA panel.
Sage Therapeutics SAGE.O jumped 2.4 % after its experimental drug met the main goal of a mid-stage study in patients with Huntington's disease.
Cleveland-CliffsCLF.N dropped3.0% after brokerage J.P.Morgan downgraded the steel stock to "neutral" from "overweight".
The Fed’s dot plot https://reut.rs/498xWRw
Reporting by Lisa Mattackal and Johann M Cherian in Bengaluru; Editing by Pooja Desai
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